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Pakistan Journal of Nutrition
Year: 2013  |  Volume: 12  |  Issue: 8  |  Page No.: 748 - 752

Preventive Effect of Corosolic Acid on Lipid Profile Against Carbon Tetrachloride-Induced Hepatotoxic Rats

Abdullah H. Al-Assaf    

Abstract: The present study was designed to investigate the hepatoprotective activity of corosolic acid in CCl4-induced hepatotoxic male albino rats and included an assessment of the antihyperlipidemic properties. Liver necrosis was induced by intraperitoneal injection of CCl4 (1.25 mL/kg b.wt.). Hyperlipidemic agents, such as lipid peroxidation, lipid profile and liver function markers were assessed. The activities of the hepatic marker enzymes such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and gamma glutamyl transpeptidase (GGT) were increased significantly in CCl4-treated animals. In the serum, increased levels of very low density lipoprotein cholesterol (VLDL-C) and low density lipoprotein cholesterol (LDL-C) and decreased high density lipoprotein cholesterol (HDL-C) were observed. Further, an increase in the levels of total cholesterol (TC), phospholipids (PL), triglycerides (TG) and free fatty acids (FFA) in serum and liver were observed in hepatotoxic rats, whereas these hepatic marker enzymes and lipid profiles were significantly protected in corosolic acid pretreated on CCl4-treated animals. These results indicate that the corosolic acid can potentially ameliorate the lipids abnormalities and protect hepatic damage against CCl4-induced hepatotoxicity rats.

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