Asian Science
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Abstract: The present study aimed to evaluate the antinociceptive and
anti-inflammatory activity of Alangium salvifolium (AS) flower in mice.
The antinociceptive activity was determined using tail immerson, acetic acid
induced writhing and formalin induced licking test. Antiinflammatory effects
were evaluated using carrageenan and formalin induced paw edema in mice. The
methanol extract (50 and 100 mg kg-1) of flower of AS followed by
chloroform extract (100 mg kg-1) produced a significant inhibition
of both phases of the formalin pain test in mice, a reduction in mice writhing
induced by acetic acid and delayed the response of mice to hot water thermal
stimulation in tail immersion test. All flowers extract of AS also produced
a substantial inhibition (nearly 50%) of carrageenan and formalin induced paw
edema. The inhibitions were similar to those produced by indomethacin, p.o.
The different alkaloids and flavonoids found in the extract could be account
for the antinociceptive and anti-inflammatory actions.