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Pakistan Journal of Biological Sciences
Year: 2009  |  Volume: 12  |  Issue: 9  |  Page No.: 746 - 749

Evaluation of IFN-γ Serum Level in Nephropatic Type 2 Diabetic Patients

Reza Nosratabadi, M.K. Arababadi, G. Hassanshahi, N. Yaghini, V. Pooladvand, Ali Shamsizadeh, E.R. Zarandi and H. Hakimi    

Abstract: The present study was aimed to examine the serum level of IFN-γ in type 2 diabetic patients with nephropatic complications. In this experimental study, serum samples were obtained from 100 type 2 diabetic patients suffering from nephropathy and 100 healthy controls. Serum level of IFN-γ was analyzed by ELISA. Results of this study showed that the mean serum level of IFN-γ was 16.09±2.04 and 4.03±1.00 pg mL-1 in nephropathic patients and healthy controls, respectively. Statistical analysis of data showed that the difference in the IFN-γ serum level was significant between nephropathic patients and controls. Due to the elevated level of IFN-γ in nephropathic patients, it can be possibly concluded that IFN-γ is involved in nephropathy complication of type 2 diabetes.

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