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Pakistan Journal of Biological Sciences
Year: 2008  |  Volume: 11  |  Issue: 3  |  Page No.: 416 - 421

Effects of Central Histamine Receptors Blockade on GABAA Agonist-Induced Food Intake in Broiler Cockerels

Zendehdel Morteza, Babapour Vahhab and Jonaidi Hossein    

Abstract: In this study, the effect of intracerebroventricular (icv) injection of H1, H2 and H3 antagonists on feed intake induced by GABAA agonist was evaluated. In Experiment 1, the animals received chloropheniramine, a H1 antagonist and then muscimol, a GABAA agonist. In Experiment 2, chickens received famotidine, a H2 receptor antagonist, prior to injection of muscimol. Finally in Experiment 3, the birds were injected with thioperamide, a H3 receptor antagonist and muscimol. Cumulative food intake was measured 15, 30, 45, 60, 90, 120, 150 and 180 min after injections. The results of this study indicated that effects of muscimol on food intake inhibited by pretreatment with chloropheneramine maleate (p<=0.05), significantly, while the famotidine and thioperamide were ineffective. These results suggest the existence of H1-receptor mediated histamine-GABAA receptor interaction on food intake in broiler cockerels

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