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Pakistan Journal of Biological Sciences
Year: 2008  |  Volume: 11  |  Issue: 9  |  Page No.: 1263 - 1267

Applied Shared Log-Normal Frailty Cox-Proportional Hazard Model to Evaluating the Effect of Vitamin A on the Rat Passive Avoidance Memory

Mohammad Reza Zadkarami    

Abstract: In this research, the Cox-proportional hazard model is used to investigate the effect of various values of vitamin A (3000, 4500 and 6000 IU kg-1) and sesame oil on the passive avoidance memory of rats by shuttle box. Present results confirm that various values of vitamin A do not improve the passive avoidance memory of rats (p<0.05). We found that the animals are clustered (p<0.001) and applying shared log-normal frailty for clustering improves present results (p<0.05) such that sesame oil improves the passive avoidance memory task (p<0.05). Therefore we should consider clustering in the analysis of biological data or we should use cloned animals.

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