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Pakistan Journal of Biological Sciences
Year: 2007  |  Volume: 10  |  Issue: 21  |  Page No.: 3769 - 3777

Use of Mycobacterial Interspersed Repetitive Unit-Variable-Number Tandem Repeat Typing to Study Mycobacterium tuberculosis Isolates from East Azarbaijan Province of Iran

Mohammad Asgharzadeh, Mansour Khakpour, Taghi Zahraei Salehi and Hossein Samadi Kafil    

Abstract: The aim of present study was to determine the genotypes of isolates from East Azarbaijan province by this method. We performed (MIRU-VNTR) analysis of strains, isolated from 127 patients during a period of September 2002 to March 2003 in tuberculosis centers of the province. Among 127 isolates, we found 93 distinct MIRU-VNTR patterns, including in 21 clustered patterns and 72 unique patterns from isolated strains. The discriminatory power of MIRU-VNTR typing in present study was high (HGDI = 0.9932) for isolates. In clusters similar patterns of Nakhichevanees patients and Iranian patients was revealed in three clusters which showed Nakhichevanees patients referred to tuberculosis centers of province could be a source for transmission of tuberculosis. Tuberculosis in this province is relatively in good condition. The allelic diversity of our samples was lower than previous studies. These results indicate that MIRU-VNTR can be a useful and first line tool for studying genetic diversity of M. tuberculosis isolates in regional setting such as East Azarbaijan province of Iran.

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