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Pakistan Journal of Biological Sciences
Year: 2006  |  Volume: 9  |  Issue: 15  |  Page No.: 2912 - 2915

Haematological Parameters of Sickle Cell Disease Patients with Menstruation Induced Vaso-Occlusive Crises

S.G. Ahmed, J. Umana and U.A. Ibrahim    

Abstract: This study evaluated the premenstrual and menstrual haematological parameters of female SCD patients with menstruation induced Vaso-occlusive Crises (VOC) with the aim of identifying any significant changes that might be etiologically associated with the crises. Fifteen female patients with sickle cell anemia (Hb SS) and history of menstruation induced VOC were studied along side equal number (15) of age and sex matched patients without history of menstruation induced VOC. Patients without history of menstruation induced VOC had mean premenstrual values of haematocrit, total leucocyte count and platelet count of 0.26 L L-1, 12x101 L-1 and 458x109 L-1, respectively, which were not significantly different from the corresponding mean menstrual values of 0.25 L L-1 for haematocrit, 11.5x109 L-1 for total leucocyte count and 452x109 L-1 for platelet count (p>0.05). Patients with history of menstruation induced VOC had mean premenstrual values of haematocrit and total leucocyte count of 0.25 L L-1 and 11.8x109 L-1, respectively, which were not significantly different from the corresponding mean menstrual values of 0.24 L L-1 for haematocrit and 12.3x109 L-1 for total leucocyte count (p>0.05). However, the mean menstrual platelet count of 605x109 L-1 was significantly higher than the mean premenstrual value of 452x109 L-1 (p<0.05). This data would suggest that high menstrual platelet count was aetiologically associated with the development of menstruation induced VOC. There is therefore the need to investigate a possible beneficial role of low doses of anti-platelet agents in preventing or managing menstruation induced VOC.

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