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Pakistan Journal of Biological Sciences
Year: 2005  |  Volume: 8  |  Issue: 3  |  Page No.: 466 - 469

Evaluation of the Onset and Offset Time of Aqueous Supernatant of Haruan (Channa striatus) Fillet Antinociception Administered Subcutaneously in Mice

Z.A. Zakaria, M.R. Sulaiman, M.N. Somchit and A.M. Mat Jais    

Abstract: The onset and offset time of aqueous supernatant of haruan (Channa striatus) fillet (ASH) antinociception was evaluated using the abdominal constriction test. The ASH, extracted using chloroform:methanol (2:1; v:v) overnight and then evaporated to remove the residual solvent, was prepared in the concentration of 10, 25 and 100% and administered subcutaneously (SC) at four different set of time (0, 5, 30 and 60 min). At the end of the respective time, acetic acid (0.6%) was administered intraperitoneally (IP) and the number of abdominal constrictions was then calculated. ASH was found to exhibit a concentration-dependent antinociception. The onset time of antinociception was found to be between 0 to 5 min depending on the concentration of ASH used with the highest and lowest concentrations of ASH produced antinociception 0 and 5 min after their administration, respectively. This activity, which increased with increase in time of ASH administration, was found to reach the highest level after 30 min of ASH administration regardless of the concentration used. The offset time, on the other hand, does not depend on the concentration of ASH used. The three respective concentrations of ASH antinociception were found to diminish completely after 60 min of their administration. Interestingly, it was also found that ASH produced activity comparable to that of acetylsalicylic acid (ASA).

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