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Pakistan Journal of Biological Sciences
Year: 2005  |  Volume: 8  |  Issue: 3  |  Page No.: 369 - 373

The Comparative Study of the Tissue Kinetics of Chloramphenicol in Healthy and Salmonella Infected Goats

E.U. Etuk and P.A. Onyeyili    

Abstract: A comparative pharmacokinetic study of chloramphenicol (25 mg kg-1 intravenous) by colorimetric assay method in tissues/organs of healthy goats and Salmonella typhimurium infected goats has revealed that, the drug was present in high concentrations in various tissues at 0.08 h (5 min) post-drug administration except in the brain of healthy goats and skeletal muscle of both healthy and infected goats. The average concentrations of the drug in the liver, kidney, spleen, bone marrow, lungs, heart and brain were higher after the infection. The residence period of the drug was higher in the kidney and the skeletal muscle of the healthy goats (240 h; 10 days). There were however decrease in the half-lives, elimination rate constants of the drug in the liver, kidney, spleen, brain, heart and skeletal muscle after the infection. The present study indicated that, a single dose of intravenous chloramphenicol injection can persist up to 10 days and a shorter period (5 days) in the edible tissues of the healthy and Salmonella infected goats, respectively. The presence of chloramphenicol in some edible tissues for up to 10 days is of public health significance.

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