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Pakistan Journal of Biological Sciences
Year: 2005  |  Volume: 8  |  Issue: 12  |  Page No.: 1746 - 1750

Biological Screening of Some Ferrocene Derivative Metal Complexes

M.E. Haque, M.Z. Rahman, M.M. Pervin, M.H. Kabir and M.S. Imran    

Abstract: The aim of the present study was to investigate the antimicrobial and cytotoxic activities of five newly synthesized ferrocene based complexes [Mn(Fcd(COO)2), A], [Co(Fcd(COO)2), B], [Ni(Fcd(COO)2), C], [Cu(Fcd(COO)2), D] and [Zn(Fcd(COO)2), E]. The maximum antibacterial (at the concentration 100 μg disc-1) and antifungal (at the concentration 200 μg disc-1) activities were shown by the manganese complex A followed by cobult complexe B. The minimum activities were shown by zinc complexe E. The minimum inhibitory concentration of the complexes was determined against four pathogenic bacteria Bacillus subtilis, Bacillus megaterinum, Escherichia coli and Shigella shiga and the values of complex A were found between 16-32 μg mL-1. Brine shirmp bioassay lethality was carried out for cytotoxicity measurements of the complexes and the LC50 values were calculated after probit transformation of the resulting mortality data. Among the five complexes manganese complex A was showed highest cytotoxic effect which is indicative of its probable effect on cancer cell lines.

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