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Pakistan Journal of Biological Sciences
Year: 2005  |  Volume: 8  |  Issue: 12  |  Page No.: 1685 - 1689

Application of a Few Waxy Materials on the Release of Naproxen from Polyethylene Glycol Based Suppositories

Sharif Mohammad Shaheen, Abdul Khalek Molla, Maruf Ahmed and A.K.M. Motahar Hossain    

Abstract: Applications of various percentages (0, 2, 4, 8, 12 and 16%) of Glycerol Mono Stearate (GMS), Stearic Acid (SA) and Cetyl Alcohol (CA) on the release rate of Naproxen (NP) from Polyethylene Glycol 4000 (PEG)-based suppositories were studied in order to reduce rectal mucosal damage and also to investigate their release pattern. Naproxen suppositories of PEG-4000 base were prepared using GMS, SA and CA separately in different formulations by fusion method. Dissolution studies showed a rapid release of the drug during 30-60 min from the PEG-based suppositories of NP and almost 65% of the drug was released within this period. But the incorporation of waxy additives GMS, CA and SA in the formulation reduces this rapid release rate of the drug. Two percent GMS containing PEG-based suppositories liberated about 69.0% of the drug within 6 h whereas maximum 45.0 and 32.0% of drug were liberated from % SA and % CA containing PEG-based suppositories, respectively, within the same time. The drug release reducing capabilities of the waxy additives were found to be in the following order CA>SA>GMS. Utilizing this capability of the additives, sustained release suppositories of Naproxen could be formulated.

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