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Pakistan Journal of Biological Sciences
Year: 2005  |  Volume: 8  |  Issue: 1  |  Page No.: 132 - 135

Effect of Fenfluramine on Molybdenum Hydroxylases Activities in Guinea Pigs

Yousuf Abdulmalik Al-Tayib    

Abstract: The effects of fenfluramine on the activities of molybdenum hydroxylases, aldehyde oxidase and xanthine oxidase, activities in the liver, kidney, small intestine and lung of guinea pigs has been investigated. Pre-treatment of guinea pigs with fenfluramine (10 mg/kg/day) for 7 days resulted in a statistically significant decrease (p<0.0005, p<0.03) in activity of liver, small intestine and lung aldehyde oxidase using phthalazine, phenanthridine and 3-methylisoquinoline as substrates. Liver and small intestine xanthine oxidase of fenfluramine treated guinea pigs was also found a statistically significant decrease in its activity (p<0.0005) using xanthine as a substrate. The Km value for phthalazine which was also a significant decrease (p<0.005) and demonstrated regarding hepatic aldehyde oxidase from fenfluramine-treated guinea pig, as compared to the phenanthridine and 3-methylisoquinoline Km values which also revealed no significant change. In addition to that, no significant change to the km value of xanthine was recorded with hepatic xanthine oxidase from fenfluramine-treated guinea pigs.

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