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Pakistan Journal of Biological Sciences
Year: 2005  |  Volume: 8  |  Issue: 8  |  Page No.: 1152 - 1156

Effects of Oral Administration of Water Extract of Nigella sativa on Serum Concentrations of Insulin and Testosterone in Alloxan-induced Diabetic Rats

Kamal Mohmoud Saleh Mansi    

Abstract: The present study was designed to evaluate the role of a medicinal plant for management of diabetes instead of manufactured drugs that led to much complication. Water extract of Nigella sativa was investigated for hypoglycemic effect in diabetic rats in addition to some hormones related to diabetes mellitus. The extract induced significant reduction in serum glucose from (7.83±1.25) to (6.7±1.10), serum insulin increased from (0.55±0.08) to (0.65±0.06) and testosterone concentration significantly increased in treated diabetic animals (7.58±0.21) compared to diabetic animals (6.63±0.58). The results suggest the beneficial role of N. sativa as hypoglycemic agents and as a protective effect against pancreatic β-cells damage from alloxan induced diabetes in rats by decreasing oxidative stress and preserving pancreatic β-cells integrity and also suggest that the anti diabetic effect of N. sativa may be attributed to increased glucose metabolism. This in turn produces increase level of insulin in serum and testosterone concentration. Which might be related with the functional activity of the reproductive glands and the correlation with the functional state of the pancreatic β-cells.

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