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Pakistan Journal of Biological Sciences
Year: 2004  |  Volume: 7  |  Issue: 5  |  Page No.: 843 - 847

Study of Cardioprotective Activity of Raphanus sativus L. in the Rabbits


Abstract: Cardio-pharmacological investigation of Raphanas sativus fruit powder, its water and ethanolic extracts was performed in rabbits to search the effective tool against cardiac disorders from natural sources. The fruit powder (0.5-1.5 g kg-1 of body weight) tested in Cyclosporin (30 mg kg-1) treated rabbits. The effects of water and ethanolic extracts of R. sativus fruit powder (Eq. to 1.5 g kg-1 of body weight) were also noted in the presence of Cyclosporin. The powder and its aqueous extract highly significantly (P<0.001) decreased the Uric acid and activity of enzymes I. e. GOT and LDH in serum of treated rabbits. Ethanolic extract did not show any significant attenuation to the cardiac effects of Cyclosporin in the rabbits. Both the fruit powder and its aqueous extract showed (in vitro) free radical-scavenging effect in a dose dependent manner on DPPH assay. R. sativus fruit powder and its aqueous extract might strengthen the antioxidant defense system to resist the free radical induced damage brought about by Cyclosporin caused ischaemic condition.

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