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Pakistan Journal of Biological Sciences

Year: 2004  |  Volume: 7  |  Issue: 4  |  Page No.: 580 - 583

Novel Bioactive Fe (III) Complexes Derived From Succinimide and Amino acids

Mst. Sabina Easmin, M. Shamim Hossain, Chanmiya Sheikh, M.Saidul Islam, M. Anwarul Islam and Mamunur Rashid


The aim of the present study was to investigate the antimicrobial and cytotoxic activities of four newly synthesized iron (III) based complexes [Fe(Suc)2(Phenylamine)2, F1], [Fe(Suc)2(Serine)2, F2], [Fe(Suc)2(Leucine)2, F3] and [Fe(Suc)2(Cystein)2, F4]. The complexes F1, F2, F3, F4 showed modest antibacterial and antifungal activities at the concentration of 200 μg disc-1 and gave MIC values between 16-64 μg ml-1 against the tested bacteria. Brine shrimp lethality bioassay was carried out for cytotoxicity measurements of the complexes and the LC50 values were calculated after probit transformation of the resulting mortality data. All the complexes showed lower cytotoxic properties compared with the reference standard gallic acid (4.53 μg ml-1) and bleomycin (0.41 μg ml-1).

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