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Pakistan Journal of Biological Sciences
Year: 2004  |  Volume: 7  |  Issue: 10  |  Page No.: 1730 - 1734

Biological Evaluation of Some Acylated Derivatives of D-mannose

Abul K.M.S. Kabir, Pijush Dutta and M.N. Anwar    

Abstract: A number of D-mannose derivatives were evaluated for in vitro antibacterial activity against eleven human pathogenic bacteria. These compounds were also screened for in vitro antifungal activity against six plant pathogenic fungi. It was observed from the study that the tested acylated derivatives of D-mannose exhibited moderate to good antibacterial and antifungal activities. The acylated D-mannose derivatives were found to be more effective against fungal phytopathogens than those of the bacterial strains. For comparative study, the biological activity of two standard antibiotics (Ampicillin and Nystatin) were also measured. It was found that the antimicrobial functionality of D-mannose increased with the introduction of various acyl substituents and in some cases, this functionality was greater than or comparable to the antibiotics studied.

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