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Pakistan Journal of Biological Sciences
Year: 2004  |  Volume: 7  |  Issue: 1  |  Page No.: 109 - 113

Studies on the Liver Function Tests (LFTs) of Obstructive Jaundice, Acute and Chronic Hepatitis Patients

Shaha Ranajit Kumar, N.K. Sana Kumar, Abdur Rauf and Mesbah Uddin    

Abstract: Liver function tests (LFTs) are almost widely used as indicators of hepatobiliary diseases. Activities of alkaline phosphatase (ALP), alanine aminotransferase (ALT), asparate aminotransferase (AST) and γ-glutamyl transpeptidase (GGT) as well as total serum bilirubin have been determined in the serum of 68 healthy volunteers (as control) and 184 hospitalized patients suffering from various hepatobiliary diseases. The total serum bilirubin levels were increased significantly (P<0.000) in obstructive jaundice and acute hepatitis patients. In both patient`s bilirubin elevation were found about 12 times higher than normal. Where as a moderately significant (P<0.001) elevated level of serum bilirubin up to 4.2 times higher than the normal was found in all chronic hepatitis, patients. Alkaline phosphatase (ALP) was found significantly (P<0.000) high about 4 times greater than the normal serum level, in obstructive jaundice. Both transaminase (ALT and AST) were dramatically and significantly (P<0.000) increased about 48 times higher than in acute hepatitis patients. The ALT/AST ratio was greater than one. In obstructive jaundice and chronic hepatitis patient`s transaminase (ALT and AST) were only mildly elevated (P<0.001). γ-glutamyl transpeptidase were significantly (P<0.000) elevated in patients with obstructive jaundice. However, in acute and chronic hepatitis the GGT level were normal or mildly high. All of them were referred for histological study of liver (liver biopsy).

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