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Pakistan Journal of Biological Sciences
Year: 2003  |  Volume: 6  |  Issue: 24  |  Page No.: 2068 - 2072

The Antinociceptive Effects of Water Extracts from Sea Cucumbers Holothuria leucospilota Brandt, Bohadschia marmorata vitiensis Jaeger and Coelomic Fluid from Stichopus hermanii

B.H. Ridzwan, T.C. Leong and S.Z. Idid    

Abstract: Sea cucumber or "gamat", as it is locally known is one of the traditional medicine that has been used until today. It is believed to help accelerate wound healing, especially after giving birth and also help to relief post-surgery pain. This experiment is to study the antinociceptive effect of water extract from sea cucumbers Holothuria leucospilota Brandt, Bohadschia marmorata vitiensis Jaeger and also the antinociceptive effect of coelomic fluid from Stichopus hermanii in mice. Two methods were used, i.e. writhing test and tail-flick test, in comparison to morphine sulphate and normal saline as positive and negative control, respectively. In the writhing test, the group of mice treated subcutaneously with control normal saline did not show a significant (p<0.05) inhibition effect. Mice group treated subcutaneously with extract and coelomic fluid of sea cucumbers (50, 75 and 100 mg kg -1) and also morphine sulphate (0.8 mg kg-1) were found to inhibit abdominal contraction induced by acetic acid (0.6%). The tail-flick test using water bath (50 ° C) showed a weak antinociceptive effect at the dose of 100 and 200 mg kg -1, but was not statistically significant (p<0.05). This effect could be seen 15 min after intraperitoneal administration of extracts or morphine sulphate (5 mg kg-1) into the mice. However, when tested statistically, both methods showed no dose-response relationship for the doses used. Hence, this study suggests the potential of water extract from H. leucospilota and B. marmorata vitiensis and the coelomic fluid from S. hermanii as alternative analgesic drug sources in the future.

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