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Pakistan Journal of Biological Sciences
Year: 2003  |  Volume: 6  |  Issue: 17  |  Page No.: 1490 - 1493

Urinary Excretion of Acetylsalicylic Acid in Female Volunteers

Kouser Fatima, Haq Nawaz Bhatti and Bushra Majeed    

Abstract: Urinary excretion of acetylsalicylic acid (aspirin) as free Salicylic Acid (SA) was observed in 12 healthy young female volunteers. After oral administration of 600 mg of drug (ASA) urine samples were collected at predetermined time intervals. Mean±SE value for pH of urine in this study was 6.04±0.14, diuresis was 0.029±0.005 mLmin–1 kg–1, concentration of free Salicylic Acid (SA) was 44.66±0.389 μg mL–1. Mean ±SE value for rate of excretion was 1.087±0.247 μg min–1 kg–1, amount excreted was 6.445±1.188 mg and percentage dose excreted was 1.076±0.197 percent. The mean ±SE value for the cumulative amount excreted was 20.85±2.708 mg and percent cumulative amount excreted was 6.45±0.64 percent. The results indicated that there was low urinary excretion under indigenous conditions.

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