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Pakistan Journal of Biological Sciences
Year: 2003  |  Volume: 6  |  Issue: 16  |  Page No.: 1413 - 1415

Urinary Excretion of Acetylsalicylic Acid in Healthy Male Volunteers

Bazghah Sadaf Siddiqui, Haq Nawaz Bhatti, Ambreen Ijaz, Saba Rasheed and Bushra Saleem    

Abstract: Acetylsalicylic acid is a non-steroidal anti-inflammatory drug. Urinary excretion of ASA (as free salicylic acid) was investigated in twelve healthy male volunteers after an oral administration of 600 mg dose. Urine samples were collected upto 10 h. The concentration of drug was determined colorimetrically and mean ±SE value in urine was found to be 37.55±0.418 μg mL–1. The values for diuresis and rate of excretion was 0.028±0.006 mL min–1 kg–1 and 0.849±0.226 μg min–1 kg–1. The amount of free SA excreted was 5.40±1.15 mg. The % dose excreted was 0.92±0.19%. Cumulative amount and % cumulative dose excreted was found to be 17.74±2.91 mg and 5.47±0.78%. There is slight variations in urinary excretion data when compared with foreign investigated values.

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