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Pakistan Journal of Biological Sciences
Year: 2003  |  Volume: 6  |  Issue: 16  |  Page No.: 1404 - 1407

Pharmacokinetic Study of Aspirin in Healthy Female Volunteers

Ambreen Ijaz, Haq Nawaz Bhatti, Saba Rasheed, Bazghah Sadaf and Rakhshanda Nawaz    

Abstract: The pharmacokinetics of acetylsalicylic acid, a non-steroidal anti-inflammatory agents, was studied in twelve healthy young females after oral administration of 600 mg aspirin. Blood samples were collected at pre-determined time intervals. The concentration of aspirin as free salicylic acid was analyzed colorimetrially at 530 nm and mean ±SE value in blood was found to be 30.33±0.63 μg mL–1. Individual pharmacokinetic parameters were estimated by using two compartment open model. Mean±SE values were found to be Cmax 44.54±0.46 mg L–1, tmax 1.87±0.05h, t1/2α 1.17±0.25 h, Ka 0.85±1.12 h–1, AUC 275±2.73 h.mg L–1, Vd 10.90±0.76 L, t1/2β 4.69±0.55 h and TBC 1.68±0.06 L h–1. ASA values established in this study were in agreement with those reported by other authors.

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