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Pakistan Journal of Biological Sciences
Year: 2003  |  Volume: 6  |  Issue: 15  |  Page No.: 1365 - 1367

Antibacterial and Cytotoxic Activities of the Metabolites Isolated from a Penicillium Strain

A.R.M. Ruhul Amin, A. Jabbar and M.A. Rashid    

Abstract: Three antibiotics (RA-1, RA-2 and RA-3) were isolated from the chloroform extract of the fermentation broth of a Penicillium strain of an unidentified species. These compounds exhibited a significant in vitro antibacterial activity against both gram-positive and gram-negative organisms. The MIC values for RA-1, RA-2 and RA-3 were also determined against Bacillus subtilis, Shigella sonnei and Escherichia coli. The chloroform extract also showed strong cytotoxicity in brine shrimp lethality assay.

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