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Pakistan Journal of Biological Sciences

Year: 2002  |  Volume: 5  |  Issue: 5  |  Page No.: 597 - 599

Antibacterial and Cytotoxic Activities of Extracts and Isolated Compounds of Ipomoea turpethum

Md. Harun-or-Rashid, M.A. Gafur, Md. Golam Sadik and Md. Aziz Abdur Rahman

Abstract

Three compounds H-1 (β-sitosteryl-β-D glucoside), H-2 (22, 23-dihydro-α-spinosteryl glucoside) & CH-2 (salicylic acid) isolated from the chloroform extract of stem of Ipomoea turpethum and the crude petroleum ether, chloroform and ethyl acetate extracts were screened against thirteen pathogenic bacteria for their antibacterial activities. The minimum inhibitory concentration (MIC) of the isolated compound CH-2 was also measured against Bacillus subtilis, Shigella dysenteriae, Sarcina lutea and Escherichia coli. The values were found to be between 128 and 256 µg/ml. The cytotoxic activity of CH-2 and chloroform and ethyl acetate extracts was also measured by brine shrimp lethality bioassay and the LC50 values were found to be 56.23, 199.53 and 31.62 µg/ml, respectively.

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