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Pakistan Journal of Biological Sciences

Year: 2002  |  Volume: 5  |  Issue: 4  |  Page No.: 484 - 488

A Comparison of Xylazine, Diazepam, Chlorpromazine and Promethazine in Relation to Certain Clinical and Hematological Parameters of Indigenous Sheep (Ovis aries)

S. Habib, B.C. Das, M.N. Islam, M.K. Hossain and M.F. Ahmed


The effect of various tranquilizer and sedative agents was studied in sheep. The respiration rates, pulse rates and rectal temperature in sheep reduced significantly (P<0.01) with all the tranquilizing and sedative agents except promethazine hydrochloride. The chlorpromazine hydrochloride produced longest onset and shortest duration of sedation and recovery period, while xylazine hydrochloride produced shortest onset and longest duration of sedation and recovery period. Xylazine hydrochloride and diazepam decreased the rumen motility significantly (P<0.01) whereas chlorpromazine hydrochloride and promethazine hydrochloride decreased insignificantly. Hemoglobin (Hb) and packed cell volume decreased significantly (P<0.01) compared with the pre-sedative control values with all the above tranquilizers and sedatives except promethazine hydrochloride. Xylazine hydrochloride reduced the PCV in a marginally significant (P<0.05) level. Promethazine hydrochloride significantly (P<0.01) increased the Hb but PCV insignificantly. Xylazine hydrochloride and diazepam produced good sedation in sheep but chlorpromazine hydrochloride produced moderate sedation whereas promethazine hydrochloride only tranquilizes the sheep.

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