Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
Pakistan Journal of Biological Sciences
Year: 2002  |  Volume: 5  |  Issue: 10  |  Page No.: 1044 - 1051

Light and Electron Microscopic Studies on the Effect of Tenoxicam on the Stomach of the Mouse

Wafaa B. Yousif    

Abstract: The effects of new nonsteroidal anti-inflammatory drug (NSAID), Tenoxicam (Epicotal), on the light and electron microscopy of the stomach of the mice were studied. Administration of daily high therapeutic dose (0.12 mg kg -1 body weight) for 30 days showed obvious pathologic changes. Extensive light microscopic changes are noticed including dilation and congestion of blood vessels and blood capillaries, a decrease of the amount of lymphoid cells in the submucosa and the lamina propria and obvious changes of the smooth muscle fibers of the stomach. Significant morphological changes in gastric gland were revealed by electron microscopy. Several unusual structural features are observed in oxyntic cells including increase in the heterochromatin in nucleus, some nuclei contain dense heterochromatin, destruction of nuclear membrane, decreased and dense mitochondria, hypertrophied golgi apparatus, decrease of tubulovesicles and myofibrils in the apical cytoplasm, fragmentation of rough endoplasmic reticulum, increase of the ribosomes and vacuolation of the connective tissue in between the blood capillary and the base of oxyntic cell. Peptic cells showed no apparent changes. In addition, the administration of high therapeutic dose of the Tenoxicam for 30 days exhibited obvious histological changes in cardiac muscles including severe congestion and dilatation of blood vessels and indentation of the muscle fibers.

Cited References   |    Fulltext    |   Related Articles   |   Back
   
 
 
 
  Related Articles

 
 
 
 
 
 
 
 
Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility