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Pakistan Journal of Biological Sciences
Year: 2001  |  Volume: 4  |  Issue: 11  |  Page No.: 1429 - 1431

Physiological Effect of LD50 of Walterinnesia aegyptia Crude Venom on Rat Metabolism Over Various Periods of Time

Ibrahim and A. Al-Jammaz    

Abstract: Serum physiological parameters are important in assessing the vital organ functions following envenomation. The effects of LD50 of the crude venom members of the snake family Elapidae, Walterinnesia aegyptia on the serum physiological parameters of white rats have been evaluated over various periods of time. The snake venom has induced a reduction in serum total protein, total albumin, uric acid, cholesterol, phosphorus, and calcium levels, as well as, the activities of LDH and AST. Serum urea, total bilirubin, creatinine, glucose, and triglycerides levels, as well as, the activities of ALT, ALP, AMY and AST were significantly increased in some of the envenomated rat groups. Thus, it appeared that W. aegyptia crude venom can cause time dependent disturbances of some of the vital organs of envenomated rats.

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