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Pakistan Journal of Biological Sciences

Year: 2000  |  Volume: 3  |  Issue: 4  |  Page No.: 555 - 557

In vivo Effects of Ibuprofen and Naproxen on the Plasma Concentration of Diltiazem in Rabbits

A.H.M. Rashidul Bari, A.T.M. Zafrul Azam, Md. Shah Amran and Md. Amjad Hossain

Abstract

An in vivo study has been carried out to evaluate the influence interaction of ibuprofen and naproxen on the plasma concentration of diltiazem in rabbits. The study has bee carried out by UV Spectrophotometric method. It has been found that the concurrent administration of diltiazem and ibuprofen has no effect on plasma concentration of diltiazem in rabbits. But concurrent administration of diltiazem and naproxen causes a significant decrease in plasma concentration of diltiazem. These results indicate that great care and monitoring is to be practiced during concurrent administration of diltiazem with naproxen to avoid untoward pharmacological and therapeutic actions related to drug-drug interactions.

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