Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
Pakistan Journal of Biological Sciences
Year: 2000  |  Volume: 3  |  Issue: 7  |  Page No.: 1104 - 1106

Studies on Biodisposition Kinetics and Urinary Excretion of Kanamycin in Goats

Asma Nafeesa, Tahira Iqbal, Munir A. Shiekh, M. Nawaz and Amer Jamil    

Abstract: The biodisposition kinetin and urinary excretion of kanamycin was investigated in eight normal adult female goats of beetle breed after intravenous close of 5 mg/kg to each gear. After single intravenous administration of kanamycin. in goats, the distribution half-life and biological hall-life had average of 8.1±0.893 min and 2.87±0.12 hrs and ranged between 4.28 to 11.61minutes and 2.44 to 3.37 hrs respectively. The aapparent volume of distribution of kanamycin in goat calculated by area method was 584.6±34.21 mg/kg. The rate constants for Lananivein transfer across compartment 1 to 2, K12 and 2 to 1, K21 were 1.846±0.316 hr–1 and 3.800±0.434 hr and ranged between 1.016 to 3.713 hr–1 and 2.45 to 5.77 hr–1, respectively. Total body clearance of kanarnycin calculated on per kg basis ranged 1.79 to 3.59 ml/min/kg with an average value 2.389±0.194 ml/min/kg, Cumulative urinary excretion as percent of total does excreated at 12 hours was 10.266±1.233. The studies showed variation in pharmacokinetic behaviour of kanamycia in indigenous goats as compared to earlier studies.

Cited References   |    Fulltext    |   Related Articles   |   Back
 
 
   
 
 
 
  Related Articles

 
 
 
 
 
 
 
 
 
Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility