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Pharmaceutical Biology

Year: 2010  |  Volume: 48  |  Issue: 3  |  Page No.: 333 - 336

Flavonoids, cinnamic acid and phenyl propanoid from aerial parts of Scrophularia striata

Hamid R. Monsef-Esfahani, Reza Hajiaghaee, Ahmad R. Shahverdi, Mohammad R . Khorramizadeh and Mohsen Amini

Abstract

No phytochemical investigation regarding Scrophularia striata Boiss. (Scrophulariaceae) has been performed, although several reports about other Scrophularia species have been published. The inhibitory effects of aerial parts of S. striata on matrix metalloproteinase expression elaborate a new approach to treat variety of malignant and inflammatory disorders. Five known compounds, including cinnamic acid, three flavonoids (quercetine, isorhamnetin-3-O-rutinoside and nepitrin) and one phenyl propanoid glycoside (acteoside 1) were isolated from S. striata Boiss. by chromatographic techniques and the structures of compounds were characterized by spectroscopic methods. This is the first report regarding the isolation of these compounds from S. striata.

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