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Pharmaceutical Biology
Year: 2009  |  Volume: 47  |  Issue: 7  |  Page No.: 620 - 623

PolySOD-catalase as a therapeutic agent with antioxidant properties

Jingsong Gu and Yuanxiu Wang    

Abstract: Antioxidant enzymes superoxide dismutase (SOD) and catalase were cross-linked with each other to form an antioxidant complex (polySOD-catalase). SOD activity was unaffected after polymerization reaction initiated by glutaraldehyde, and catalase activity was modestly decreased. In an oxidative stress model, where a xanthine/xanthine oxidase system was employed to generate superoxide radicals, catalase located at sufficient proximity to SOD after polymerization reaction provided effective protection for SOD from oxidative damage. In vivo evaluation indicated the antioxidant complex of polySOD-catalase had an extended circulation time suitable for therapeutic utility. As measured in anesthetized rate, polySOD-catalase can remain circulating with a half-life of as much as 6 h. Such a polymerization formulation could be a candidate therapeutic agent for age-related diseases associated with reactive oxygen species.

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