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Pharmaceutical Biology
Year: 2009  |  Volume: 47  |  Issue: 6  |  Page No.: 509 - 515

Effects of Myristica fragrans oil on the reproductive organs of male albino rats

Meera Agarwal, Alka Chauhan and Teena Gehani    

Abstract: This research aimed to study the effects of Myristica fragrans Houtt. (Myristicacae) oil on male reproductive functions in Wistar strain rats, the oil of Myristica fragrans at the dose levels of 0.2, 0.4, and 0.5 mL/kg body weight/day for 60 days. The oil reduced fertility to 0% by 60 days of treatment at the highest dose level. The results also revealed the oil caused significant reduction in the weight of testis, epididymis, seminal vesicle, ventral prostate and vas deferens. Sperm motility as well as sperm density were significantly reduced which resulted in the reduction of male fertility by 100% at the highest dose level tested. Leydig cell nuclear area and mature Leydig cell numbers were significantly reduced when compared with controls. The round spermatids were decreased by 72.71%. The hematological parameters show a non-significant change when compared with the control group. A recovery of 80% fertility was recorded after withdrawal of 120 days, proving that the drug is safe to use. These results suggest the antifertility and recovery effect from the oil of Myristica fragrans in male albino rats.

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