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Pharmaceutical Biology
Year: 2009  |  Volume: 47  |  Issue: 12  |  Page No.: 1149 - 1153

Antidiabetic and antioxidant activity of the methanol extract of Diospyros peregrina fruit on Type I diabetic rats

Saikat Dewanjee, Ranabir Sahu, Vivekananda Mandal, Anup Maiti and Subhash C. Mandal    

Abstract: Chronic diabetes complications are mainly associated with augmented oxidative stress. Thus the present study evaluated the hypoglycemic, as well the antioxidant effect, of the methanol extract of Diospyros peregrina Gurke. (Ebenaceae) fruits on experimental diabetic rats. Oral administration of methanol extract at 150 and 300mg/kg body weight per day to diabetic rats was found to have profound hypoglycemic activity in term of reduction of fasting blood glucose level. The diabetic rats showed lower activities of superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (GSH) content in hepatic and renal tissues as compared with normal rats. The activities of SOD, CAT, and GSH were found to be increased in extract-treated diabetic rats in selected tissues. The increased levels of lipid peroxidation (thiobarbituric acid reactive substances and hydroperoxides) in diabetic rats were also found to be reverted back to near-normal status in extract-treated groups. It was found that the extract is more effective at the dose of 300mg/kg body weight and this effect is almost comparable to that of standard glibenclamide.

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