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Natural Product Research Part A

Year: 2009  |  Volume: 23  |  Issue: 10  |  Page No.: 963 - 972

Structure and activities of a steroidal saponin from Chlorophytum nimonii (Grah) Dalz

Vijai Lakshmi, Rajesh Kumar, Kartikey Pandey, Bhawani Shanker Joshi, Raja Roy, Kunnath Padamnabham Madhusudanan, Priti Tiwari and Arvind Kumar Srivastava


A new steroidal saponin, chloragin (1), was isolated and characterised from the aerial part of Chlorophytum nimonii. The structure of chloragin (1) was established as tigogenin-3-O-agr-L-rhamnopyranosyl-(1 → 4)-β-D-glucopyranosyl-(1 → 3)-β-D-xylopyranosyl-(1 → 4)-β-D-glucopyranosyl-(1 → 4)-β-D-xyloopyranoside on the basis of detailed chemical and spectral evidence. The saponin showed potent antihyperglycaemic and antidyslipidaemic activities in albino rats.

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