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Natural Product Research Part A
Year: 2009  |  Volume: 23  |  Issue: 17  |  Page No.: 1609 - 1614

Bioactive flavonoids from Satureja atropatana Bonge

Ahmad R. Gohari, Soodabeh Saeidnia, Mahmood R. Gohari, Fahimeh Moradi-Afrapoli, Maryam Malmir and Abbass Hadjiakhoondi    

Abstract: From the ethyl acetate and methanol extract of the aerial parts of Satureja atropatana Bonge, which belongs to the Lamiaceae family, four flavonoids were isolated. Their structures were determined to be 5,6,3’-trihydroxy-7,8,4’-trimethoxyflavone (1), 5,6-dihydroxy-7,8,3’,4’-tetramethoxyflavone or 5-desmethoxynobiletin (2), 5,6,4’-trihydroxy-7,8,3’-trimethoxyflavone or thymonin (3) and luteolin (4) using 1H and 13C-NMR and MS spectra. Brine shrimp cytotoxicity effects of the crude extracts and isolated compounds were examined. Berberine hydrochloride (LC50 = 26 g mL-1) was used as a positive control. Among them, compounds 2 (199 g mL-1) and 3 (157 g mL-1) were effective against Artemia salina larva.

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