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Natural Product Research Part A
Year: 2009  |  Volume: 23  |  Issue: 16  |  Page No.: 1522 - 1527

A furanocoumarin from Prangos uloptera roots, biological effects

Seyed Mehdi Razavi, Saber Zahri, Hossein Nazemiyeh, Gholamreza Zarrini, Sariyeh Mohammadi and Mohammad-Amin Abolghassemi-Fakhri    

Abstract: A known furanocoumarin, 8-geranyloxy psoralen, was isolated from n-hexane extract of Prangos uloptera roots by the TLC method. Its structure was determined by comparison of the spectral data with the literature. Cytotoxic effects of the isolated compound were determined by MTT and Tripan blue assays. The antioxidant and antimicrobial potential of the compound were evaluated by DPPH assay and agar dilution method, respectively. The MTT assay results showed that 8-geranyloxy psoralen reduced cell viability of Hela and Mc-Coy cell lines with IC50 values of 0.792 and 0.835 mM, respectively. Based on the Tripan blue asay, the compound has cytotoxic effects, with an IC50 value of 1.26 mM for Mc-Coy cell line. The compound exhibited weak antioxidant potential, with an RC50 value of 0.262 mg mL-1 and high antimicrobial effects against Staphylococcus epidermidis and Candida kefyr.

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