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Natural Product Research Part A
Year: 2008  |  Volume: 22  |  Issue: 17  |  Page No.: 1498 - 1509

Microbial transformation of testosterone by Rhizopus stolonifer and Fusarium lini

Amal Al-Aboudi, Mohammad Yasin Mohammad, S. Ghulam Musharraf, M. Iqbal Choudhary and Atta-ur- Rahman    

Abstract: The microbial transformation of testosterone by the fungi Rhizopus stolonifer and Fusarium lini has been investigated for the first time. The bioconversion reactions observed from R. stolonifer included oxidation of a 17β-hydroxyl group, a hydroxylation at equatorial 11α position, reduction of the double bond at C-4 with oxidation of the methylene at C-6 to the corresponding keto group, and lactonisation of ring D; the latter is the first report of this reaction by a Rhizopus species. Fusarium lini promoted 1-dehydrogenation of the steroid, which has been rarely observed in fungi cultures. The other routes of biotransformations included oxidation of the 17β-hydroxyl group and the hydroxylation at 11α position. These reactions are not common for Fusarium species.

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