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Natural Product Research Part A
Year: 2008  |  Volume: 22  |  Issue: 15  |  Page No.: 1289 - 1296

Microbial oxidation of anabolic steroids

M. Iqbal Choudhary, S. Adnan, A. Shah and Atta- Ur-Rahman    

Abstract: Microbial transformation of two anabolic steroids, ethylestrenol (1) and nandrolone (2), were carried out. Ethylestrenol (1), when incubated with Rhizopus stolonifer (TSY 0471), yielded two oxidative metabolites named 17β-ethyl-3β,17β-dihydroxy-19-norndrost-4-ene (3) and 17β-ethyl-17β-hydroxy-19-norandrost-4-en-3-one (4), while incubation of compound 2 with the same fungus yielded two oxidative metabolites, 19-norandrost-4-en-3,17-dione (5) and 6β,17β-dihydroxy-19-norandrost-1,4-dien-3-one (6).

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