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MHR: Basic science of reprod. Medicine
Year: 2010  |  Volume: 16  |  Issue: 4  |  Page No.: 267 - 272

Role of Toll-like receptor 4 in inflammation-induced preterm delivery

L Li, J Kang and W. Lei    

Abstract:

The aim of the present study was to investigate the potential role of Toll-like receptor 4 (TLR4) in lipopolysaccharide (LPS)-induced preterm delivery. Intraperitoneal injection of LPS in the presence or absence of previous TLR4 blockade was performed to establish a murine model of preterm delivery. The incidences of preterm delivery and fetal death were calculated. Flow cytometry was performed to examine the percentages of blood CD45+CD86+, CD3+CD69+, CD19+CD69+ and CD49b+CD69+ cell subsets, and the percentages of placenta CD45+CD86+, CD45+CD49b+ and CD49b+CD69+ cell subpopulations. In our study, an inflammation-induced preterm delivery model was established by intraperitoneal injection of LPS. Blocking TLR4 significantly decreased LPS-induced preterm delivery and fetal death. LPS treatment markedly up-regulated the percentages of blood CD45+CD86+, CD3+CD69+ and CD49b+CD69+ cells, and of placenta CD45+CD86+, CD45+CD49b+ and CD49b+CD69+ cells. TLR4 blockade almost completely abrogated LPS-induced elevated cell proportions. These data demonstrate that TLR4 plays a critical role in inflammation-induced preterm delivery.

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