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Kidney Research Journal
Year: 2012  |  Volume: 2  |  Issue: 1  |  Page No.: 12 - 17

The Acute Toxicity of Deisopropylngaione in Mice

E.A. Ogunsan, A.A. Seawright, D.O. Ehizibolo, H.M. Tukur, M.S. Ahmed, Y.G. Dashe and M.Y. Sugun    

Abstract: It has become apparent that inflammation provoked by injury to renal epithelial cells serves to amplify kidney injury and dysfunction in vivo Compounds including the sesquiterpene ketones generally believed to cause kidney injury by direct tubular toxicity or crystal nephropathy have been considered in different renal studies. The aim of this study was to highlight the histotoxicity of Deisopropylngaione (DIN) in mice. Ninety male quackenbush mice weighing between 30 and 35 g b.wt. were divided into five groups of fifteen mice per group and received 70, 98, 137, 192 and 268 mg kg-1 DIN intraperitoneally, respectively. Haematoxylin erosin (H and E) and Von Kossa stained histology slides showed proximal tubular necrosis and hyaline cast formation. Deposition of calcium salt in residual necrotic tubular epithelium was on the increase with increase in dose rate. Besides the pulmonary lesions seen in mice following intoxication by DIN, the kidney lesions were consistent with previous studies of these compounds in mice and similar to mercuric chloride poisoning in sheep.

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