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Journal of Pharmacology and Toxicology
Year: 2020  |  Volume: 15  |  Issue: 1  |  Page No.: 1 - 7

Effects of Ethanolic Leaf and Stem-bark Extracts of Adansonia digitata in Alloxan-induced Diabetic Wistar Rats

Ojochenemi Ejeh Yakubu, Chinedu Imo, Christopher Shaibu, John Akighir and Daniel Simon Ameh    

Abstract: Background and Objectives: Diabetes mellitus has been a great worry to humanity and the scientific community and researchers have made it a point of challenge and responsibility to bring an end to the quantum of havocs posed by this monster. This study was carried out to evaluate the effects of ethanolic leaf extract and stem-back extract of Adansonia digitata (AD) on liver function, haematology and blood glucose level in alloxan-induced diabetic Wistar rats. Materials and Methods: Twenty-five Wistar rats were distributed into 5 groups of 5 animals each. The test animals were administered alloxan (150 mg kg1) intraperitoneally and were monitored for 72 h for the development of hyperglycemia. Group 1 served as normal control, group 2 served as diabetic control, while groups 3and 4 were diabetic rats treated orally with ethanolic leaf and stem-bark extracts of Adansonia digitata (100 mg kg1), respectively for 21days. Group 5 animals were diabetic rats treated with anti-diabetic drug (glibenclamide). Results: The result of this study indicated a reduced blood glucose level and a significantly (p<0.05) reduced liver function parameters evaluated in the alloxan-induced diabetic treated rats compared with the diabetic control rats. However, there was no specific pattern of increase/decrease in the haematological parameters. Conclusion: This study showed that alloxan-induced diabetes mellitus caused a possible liver disease condition and alteration of the haematological indices. However, administration of the AD leaves extract and AD stem-bark extract exhibited the ability of treating the inflammation and alterations caused by alloxan-induced diabetes.

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