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Journal of Pharmacology and Toxicology

Year: 2017  |  Volume: 12  |  Issue: 1  |  Page No.: 24 - 32

Ameliorating Effect of Zinc Against Oxidative Stress and Lipid Peroxidation Induced by Fipronil in Male Rats

Eman S. Swelam, Ibrahim S. Abdallah and Abdel-Tawab H. Mossa


Objective: The present study was carried out to investigate the protective effect of zinc against oxidative damage induced by fipronil (FPN) in the liver and kidney of male rats. Methodology: Rats were assigned to four groups and received, water (control group), fipronil at concentration 10 mg L–1 (2.0 mg kg–1 b.wt.), zinc at concentration 227 mg L–1 and fipronil plus zinc group. All treatments were administered through drinking water for 45 days. The concentration used of fipronil in this study represents 2.0 mg kg–1 b.wt., based on average water consumptions and body weights of treated rats. Results: Results revealed that fipronil induced insignificant changes in body weight and significant increase in liver weight of treated rats. Also, significant activities of oxidative stress enzymes such as, superoxide dismutase (SOD), glutathione-s-transferase (GST), glutathione peroxidase (GPx), catalase (CAT) and level of glutathione reduced (GSH) were obtained. The FPN caused a significant elevation in lipid peroxidation level. However, the adverse effects induced by FPN were mitigated when the rats were supplemented with zinc. Moreover, three new protein bands were detected only in the electrophoretic pattern of the FPN treated group and disappeared in the remaining three groups; control, zinc and fipronil plus zinc. Conclusion: The overall outcome suggested that FPN induced adverse effects on oxidant/antioxidant status in the liver and kidney of intoxicated rats and zinc has a role in attenuating these effects. These outcome show that administration of Zn may be useful, easy and economical to protect human against phenyl pyrazole insecticide toxic effects.

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