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Journal of Pharmacology and Toxicology
Year: 2017  |  Volume: 12  |  Issue: 3  |  Page No.: 154 - 160

Modulatory Effect of Achyranthes aspera L., Seeds on Carbohydrates and Protein Bound Enzymes on High Fructose Fed Diet

Veerappan Ramanathan and Malarvili Thekkumalai    

Abstract: Background and Objectives: High fructose feeding in rats not only induces insulin resistance, but it may also induce hyperinsulinemia, hyperglycemia and dyslipidemia. Achyranthes aspera (A. aspera) exhibited potent hypolipidimic activity. This study’ investigated the effects of A. aspera on the content and characteristics of carbohydrate bound enzymes and protein bound carbohydrates of rats with high fructose fed diet (HFFD). Materials and Methods: The insulin resistance in fructose-fed rats is associated with the defects in insulin signalling pathways. Twenty four male wistar rats were randomly divided into four groups of six animals each. Normal Control group I, A. aspera supplemented control group II, A. aspera not supplemented group III and supplemented fructose-fed group IV. The estimation of carbohydrate bound enzymes and protein bound carbohydrates were studied. Statistical analysis was performed using one way analysis of variance (ANOVA) followed by Duncan’s Multiple Range Test (DMRT) using SPSS software package 19.0 (significant value p<0.05). Results: Administration of A. aspera results in significant reduction of hexokinase D, glucose-6-phosphatase (G-6-P) and fructose-1, 6-bisphosphatase (F-1, 6-P) activities, hexose, hexosamine, sialic acid and fucose in plasma. Conclusion: It was concluded that A. aspera treatment was found to be effective in improving insulin sensitivity and metabolic alterations of carbohydrate and protein associated with consumption of HFFD.

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