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Journal of Pharmacology and Toxicology
Year: 2017  |  Volume: 12  |  Issue: 3  |  Page No.: 142 - 147

White and Oolong Tea Extracts Inhibition of Fibroblast and Cancer Cell Proliferation Unrelated to the Proanthocyanidins Constituent

Marwan Salih Mohamud Al-Nimer, Huda Ghassn Hameed and Nahi Youssif Yaseen    

Abstract: Background: Proanthocyanidins are bioactive compounds, found in herbal medicines including, the Camellia sinensis plant that exhibited an antioxidant and anticancer activities in both in vitro and in vivo models. Objective: This study aimed to investigate the cytotoxic effect of white and oolong tea against cancer cells and fibroblasts and to link these effects to their content of the proanthocyanidins level. Materials and Methods: An aqueous white and oolong tea extracts (10% w/v) prepared by a microwave assisted method. Proanthocyanidins content in each extract is determined and its levels expressed as catechins. The cell lines belonged to HeLa, human rhabdomyosarcoma, mammary (AMN3) adenocarcinoma and primary rat embryo fibroblast cell lines were incubated with each tea extract (equivalent to 2.5 mg of dry weight tea) in RPMI-1640 culture media supplemented with 5% fetal calf serum. Statistical analysis achieved by using Student's t test and difference between percentages test. Results: The mean levels of proanthocyanidins in oolong tea found to be four times of that in white tea extract. The extracts of white and oolong tea significantly inhibit the growth of fibroblasts (30.6 and 24%), HeLa (32.7 and 35.3%) and rhabdomyosarcoma cells (66.3 and 59%) of the initial percentage of the cells that did not treat with tea extracts. White and oolong tea extracts did not significantly inhibit the growth of mammary-AMN3 adenocarcinoma cell line (91.7 and 77.8% versus 100%). Conclusion: White and oolong tea extracts inhibit the growth of cancer cells and fibroblasts by a mechanism that does not relate to the antioxidant-bioactive substance the proanthocyanidins.

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