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Journal of Pharmacology and Toxicology
Year: 2016  |  Volume: 11  |  Issue: 1  |  Page No.: 11 - 19

Comparative Pharmacokinetics of Intramuscular Sulphadimidine in Non-starved and Starved Grower Turkeys (Meleagris gallopavo)

Agbo Joseph Odeh, Saganuwan Alhaji Saganuwan and Onyeyili Patrick Azubuike    

Abstract: Background: Sulphadimidine has maintained an active place in the armamentary of avian medicine. Objective: In view of this, comparative pharmacokinetic parameters were studied in starved and non-starved grower turkeys. Methodology: In a randomized parallel study, the pharmacokinetics of sulphadimidine sodium (100 mg kg–1 b.wt.) was obtained in non-starved healthy male and female grower turkeys (n = 20) and starved male and female grower turkeys (n = 20) after a single intramuscular administration. The mean peak serum concentrations of sulphadimidine were 99.42±3.81 μg mL–1 at 1.5 h in non-starved male turkeys and 127.68±10.37 μg mL–1 at 2 h in starved male turkeys, respectively. The mean elimination half-lives were 7.62±0.51 and 12.76±1.52 h in non-starved and starved male turkeys, respectively. Results: The mean peak serum concentrations of sulphadimidine were 99.42±3.81 μg mL–1 at 1.5 h in non-starved male turkeys and 127.68±10.37 μg mL–1 at 2 h in starved male turkeys, respectively. The mean elimination half-lives were 7.62±0.51 and 12.76±1.52 h in non-starved and starved male turkeys, respectively. The mean peak serum concentration of sulphadimidine at 2 h (86.70±6.46 μg mL–1) in non-starved and 1.5 h (121.62±8.55 μg mL–1) in starved female turkeys were recorded, respectively. The mean elimination half-lives were 9.99±1.31 and 14.39±1.52 h in non-starved and starved female turkeys, respectively. Based on target MIC of ≥50 μg mL–1 in serum, sulphadimidine was maintained above this level for 10 and 18 h in non-starved and starved male and female Turkeys, respectively. Conclusion: The study indicates that sulphadimidine sodium should be administered to anorexic male and female turkeys infected with coccidia and bacteria sensitive to sulphadimidine every 18 h interval. For prophylaxis, sulphadimidine can be administered intramuscular every 10 h interval.

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