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Journal of Pharmacology and Toxicology
Year: 2014  |  Volume: 9  |  Issue: 3  |  Page No.: 110 - 118

Effect of Methonolic Pericarp Extract of Feronia limonia on Hypoglycemic and Antihyperglycemic Activities in Normal and Streptozotocin Induced Diabetic Rats

Swathi Putta and Eswar Kumar Kilari    

Abstract: Diabetes mellitus is a chronic metabolic disorder characterized by raise in blood glucose levels known as hyperglycemia. In the present study, the methonolic pericarp extract of Feronia limonia (MPFL) was evaluated for hypoglycemia and its antihyperglycemic activity in streptozotocin-induced diabetic rats. The percentage inhibition of blood glucose levels in hypoglycemic activity of MPFL 150 and 300 mg kg-1 were found to be 26.91±0.53 (3 h) and 34.67±0.93 (6 h) and 22.53±0.32 (3 h) and 25.24±0.78 (6 h) hypoglycaemic normal rats. The antihyperglycemic activity of MPFL with 150 and 300 mg kg-1 in STZ induced diabetic rats were found to be 31.38±0.77 and 35.42±0.71 at 6 h, respectively. The biphasic reduction was observed in both in normal and diabetic rats might be due to biphasic absorption or biliary secretion of the active principle present in MPFL. Further the samples from diabetic rats were estimated for lipid profile. The lipid profile parameters were significantly brought back to near normal by the treatment if MPFL for 12 weeks. At the end of 12 weeks study period the serum parameters like bilirubin, creatinine, total protein, albumin, uric acid and urea were found to be increased in diabetic rats and treatment with MPFL there is a significant reduction in all the parameters. So, the MPFL found to have significant antihyperglycemic, antihyperlipedemia activity and significant protection against the damage to kidney. Which might be due to antioxidant potential present in the MPFL.

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