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Journal of Pharmacology and Toxicology
Year: 2013  |  Volume: 8  |  Issue: 1  |  Page No.: 42 - 48

Anticancer Activity of Andrographis paniculata and Silybum marianum on Five Human Cancer Cell Lines

S. Singh, A. Mehta, S. Baweja, L. Ahirwal and P. Mehta    

Abstract: Andrographis paniculata and Silybum marianum are well known medicinal plants. However, to prove their efficacy for clinical utilization more scientific data are needed. Therefore, in the present study, an attempt was made to investigate the anticancer potential of hydroalcoholic extracts of A. paniculata and S. marianum and their combination (1:1). The sulphorhodamine B (SRB) assay was used to assess growth inhibition of human tumor. Five human cancer cell lines i.e., human breast adenocarcinoma (MCF-7), human cervix (SiHa), Colon (HT-29), Ovary cancer cell line (ovcar-5) and Liver (HepG2) were used for the above study. The results obtained suggest that S. marianum hydroalcoholic extract showed the best cytotoxic activity against all given cell lines with percentage inhibition of 21.34, 32.30, 46.56, 59.58, 36.20 for MCF 7, SiHa, HT-29, Ovcar-5 and HepG2, respectively. While, A. paniculata hydroalcoholic extract was found most effective against Ovcar-5 with 51.12% inhibition. The combination of both the plants (1:1) showed an intermediate result for all the cell line but, it was found to be most effective against HepG2 with 42.76% inhibition. The results obtained in the study indicate that A. paniculata and S. marianum possess significant anticancer activity and have the therapeutic potential to prevent the cancerous diseases.

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