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Journal of Pharmacology and Toxicology
Year: 2012  |  Volume: 7  |  Issue: 1  |  Page No.: 38 - 45

Efficacy of Momordica charantia in Attenuating Hepatic Abnormalities in Cyclophosphamide Intoxicated Rats

N. Nithya, K. Chandrakumar, V. Ganesan and S. Senthilkumar    

Abstract: Cyclophosphamide (CP) is one among the important therapeutic chemotherapy drug used worldwide. Damage to normal tissues due to toxic metabolites limits the usage of CP efficiently for treating various cancers. In the present study, hepatoprotective effect of Momordica charantia Linn. (Cucurbitaceae) against CP induced hepatotoxicity in rats was evaluated. Hepatocellular damage in rats was induced by injecting CP i.p. (total of 200 mg kg-1, b.wt.) for 2 days. Momordica charantia fruit aqueous extract (MCE) (300 mg kg-1 b.wt.) was administered orally for 12 days for treatment. Protective effect of MCE was evaluated by assessing the liver marker enzymes such as AST, ALT, ALP, LDH and γ-GT in serum, AST and ALT in liver tissues and biochemical parameters such as total protein, urea, creatinine, uric acid, total and direct bilirubin. Liver marker enzymes and clinical chemistry parameters were significantly altered in CP intoxication. These alterations were significantly normalized in animals administered with MCE. Protective effect of MCE could be due to radical-scavenging and antioxidant properties of the MCE. MCE could had been demonstrated these properties due to the presence of phytochemical components that include polyphenols, alkaloids, terpenoids, glycosides and tannins. Present findings supported that the treatment with MCE could be helpful against hepatocellular damage, owing to its hepatoprotective property.

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