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Journal of Pharmacology and Toxicology

Year: 2012  |  Volume: 7  |  Issue: 7  |  Page No.: 312 - 321

Haemato-biochemical Effects of Formulated and Technical Cypermethrin and Deltamethrin Insecticides in Male Rats

Moustafa A. Abbassy and Abdel-Tawab H. Mossa


Pesticide formulations are complex mixtures and the toxicity information on active ingredients alone is not sufficient to evaluate the risk of adverse health effects of commercial pesticides. So, the present work was conducted to study the haemato-biochemical effects of technical and formulated cypermethrin (25.0 mg kg-1 b.wt.) and deltamethrin (1.70 mg kg-1 b.wt.), in male rats given repetitive oral doses for 90 consecutive days. There was high significant decrease (p≤0.01) in body weight gain of cypermethrin and significant decrease (p≤0.05) in deltamethrin treated rats. The relative liver and kidney weights were significantly change in the treatments of formulated and technical cypermethrin and deltamethrin compared to the control. Deltamethrin as technical or formulated form caused significant changes (p≤0.01) in haemoglobin, packed cell value and Red Blood Cell (RBC), while formulated and technical cypermethrin caused significant decrease (p≤0.05) in PCV % and formulated cypermethrin induced significant decrease (p≤0.01) in White Blood Cell (WBC) compared to control value. Treatments with formulated and technical cypermethrin and deltamethrin caused significant increase (p≤0.01) in serum Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) activities and formulated cypermethrin seemed to induce higher AST elevation (200.67 IU L-1) and formulated deltamethrin induce higher ALT elevation (105.07 IU L-1) as compared with the untreated group (21.30 and 25.50 IU L-1, respectively). Technical cypermethrin and deltamethrin caused highly significant (p≤0.01) decreased in serum glucose. On the other hand all of the tested insecticides induced significant decreases (p≤0.05) in serum total protein and increase (p≤0.05-0.01) in creatinine and uric acid concentrations. The partial differences of hematological and biochemical effects obtained with pure and commercial deltamethrin and cypermethrin indicate that commercial formulations may contain additional hazardous compounds. Therefore, it is important in assessing the real human hazard from pesticides to investigate not only the active principle but also the commercial formulations used in agriculture.

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