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Journal of Pharmacology and Toxicology
Year: 2012  |  Volume: 7  |  Issue: 4  |  Page No.: 206 - 212

Phenolic Content, Antioxidant Capacity and Toxicity of 3 Varieties of Living Stone Potato (Rizga)

C.O. Eleazu, K.C. Eleazu and A.I. Ikpeama    

Abstract: The phenolic content, antioxidant activity and toxicity of three varieties of extracts of rizga flour on white albino male rats was evaluated. The antioxidant activities of the extracts as determined by the quantities of phenols present and scavenging activities on 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical indicated that all three varieties of rizga flour contained significant quantities of antioxidants and phenols. However, the total antioxidant capacity and polyphenolic contents of langaat was lower than that of beebot and riyom (p<0.05) with an IC50 of 90.16 μg mL-1 for langaat, 30.28 μg mL-1 for beebot and 60.27 μg mL-1 for riyom as compared with the standard (Quercetin) that had an IC50 of 23.17 μg mL-1. The phytochemical screening of the flours was determined using standard qualitative methods indicated the presence of cyanogenic glucosides, tannins and flavonoids in all the three varieties studied but beebot and riyom contained alkaloids in addition. The extracts of the 3 varieties of rizga had a low toxic effect on the rats studied in addition with an LD50 of 630.1 mg kg-1 for Riym, 398.1 mg kg-1 for Langaat and 446.7 mg kg-1 for Beebot. Correlation between the total antioxidant capacity and polyphenolic composition of the 3 varieties of rizga was found to be significant (R2 = 0.917). These findings suggest rizga to be a natural source of antioxidants and thus could be used in the treatment of ailments implicating free radicals. In addition, it is safe for consumption.

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