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Journal of Pharmacology and Toxicology
Year: 2012  |  Volume: 7  |  Issue: 4  |  Page No.: 181 - 191

Effects of Methanol Extract of Buchholzia coriacea Fruit in Streptozotocin-induced Diabetic Rats

Chinaka O. Nwaehujor, Okwoche J. Ode, Florence C. Nwinyi and Nkeiruka E. Udeh    

Abstract: The hypoglycemic and anti-oxidant effects of the methanolic extract of Buchholzia coriacea fruits in streptozotocin-induced diabetic rats were investigated. It was tolerated up to dose of 2000 mg kg-1 orally in rats. Treatment with 150, 300 and 600 mg kg-1 of the extract induced significant (p<0.05) dose dependent decreases in the respective fasting blood glucose values of 6.61+2.14, 5.12+1.01 and 3.84+0.81 mmol L-1 from the initial mean value of 14.15±5.12 mmol L-1 when compared with the negative control. Glibenclamide (2 mg kg-1) however, lowered the fasting blood glucose to 3.51±0.75 mmol L-1. The serum concentrations of catalase and reduced glutathione were significantly (p<0.05) higher in rats treated with glibenclamide (2 mg kg-1) and various doses (150, 300 and 600 mg kg-1) of the extract in contrast to the values in negative control rats. The extract also decreased serum triglycerides and total serum cholesterol. The fruit extract dose dependently reduced lipid peroxidation in diabetic rats. The ability of scavenging free radicals was measured by DPPH reduction and Ferric Reducing/Antioxidant Power (FRAP) spectrophotometric assays. In the DPPH assay, the highest concentration (400 μg mL-1) of the extract produced 66% antioxidant activity compared to 80% with ascorbic acid at the same concentration. The FRAP value increased concentration dependently from 1.1 to 1.7 μM (100-400 μg mL-1) while ascorbic acid has a FRAP value of 2 μM at 1000 μg mL-1. The findings suggest that the extract could be a potential source of a novel anti-diabetic and antioxidant agent.

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